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TIAMULIN HYDROGEN FUMARATE PREMIX 80%

TIAMULIN HYDROGEN FUMARATE PREMIX 80%

Region: Shandong
Monthly Production Capacity: 120TON
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Detailed Description
  • Packaging Information: 20KG/FIBER DRUM
  • Main Sales Markets: North America, Central/South America, Western Europe, Eastern Europe, Australasia, Asia, Middle East
  • Sample Provided: no
  • Chemical name:

(3aS,4R,5S,6S,8R,9R,9aR,10R)-6-Ethenyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propano-3aH-cyclopentacycloocten-8-yl[[2-(diethylamino)ethyl]sulphanyl]acetate hydrogen (E)-butenedioate.

  • Chemical abstract service (CAS) registry number: 55297-96-6
  • Molecular formula: C28H47NO4S·C4H4O4
  • Relative molecular mass: 609.82
  • Appearance: White or off-white granules.
  • Loss on drying: Not more than 4.0%.
  • Particle size

    All pass 24mesh sieve, the quantity through 80 mesh sieve should be not more than 10.0%.

  • pH: A 1% solution (g/ml) in water has a pH of 3.1 to 4.1.
  • Packaging and storage

    Preserve in tight, light-resistant containers, and store at room temperature.

  • Pharmacological properties

    Tiamulin fumarate is a semi-synthetic diterpene antibiotic. The mode of action is by inhibition of ribosomal protein synthesis in sensitive bacteria. It is a bacteriostatic antibiotic and the following organisms show sensitivity in vitro:

Brachyspira: Brachyspira hyodysenteriae, Brachyspira pilosicoli

Mycoplasmas: Mycoplasma hyopneumoniae, M.hyorhinis, M. hyosynoviae, Ureaplasma spp.

Gram-positive: Staphylococcus spp., Streptococcus spp., Corynebacterium pyogenes.

Gram-negative: Pasteurella spp., Klebsiella pneumoniae, Actinobacillus (Haemophilus) spp., Fusobacterium necrophorum, Bacteroides spp., Campylobacter coli, Lawsonia intracellularis.

    Following oral administration, tiamulin fumarate is rapidly absorbed and peak serum concentrations are achieved 2 - 4 hours after administration and concentrates in some tissues e.g. lung. Following absorption, it is rapidly metabolized and excreted.

  • Indications

    For the treatment, prevention and control of swine dysentery caused by Brachyspira hyodysenteriae and complicated by Fusobacterium and Bacteroides spp. As an aid in the control of the enzootic pneumonia complex in pigs.

  • Usage and dosage

    Mix with feed:

    For pig: Every 1000kg feed, 40~100g Tiamulin fumarate, for 5~10 days consecutively.

  • Withdrawal period: 7 days for pig.
  • Contra-indications

    Animals should not receive products containing monensin, narasin or salinomycin, during or for at least seven days before or after treatment with tiamulin.

  • Shelf life: 2 years.

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