Join Free For Buyer|Sign In

Professional Online Trade Platform for API, Preparation and Pharmaceutical Machinery and

You are here:  Home >>  News >>  Market News >>  Janssen files nasal spray for depression

Janssen files nasal spray for depression

October 12, 2018 By pharmatimes

The drug has been developed for treatment-resistant depression (TRD) in adults with MDD who have not responded to at least two different treatments with antidepressants in the current moderate-to-severe depressive episode.

Esketamine is a glutamate receptor modulator thought to help restore synaptic connections in brain cells in people with TRD, offering a rapid-acting novel mechanism of action and the first new treatment option for 30 years.

The firm presented data earlier this year showing that continuing treatment with esketamine nasal spray plus an oral antidepressant in patients beyond 16 weeks “showed clinically meaningful and statistically significant superiority” to treatment with an oral antidepressant plus placebo nasal spray in delaying time to relapse of symptoms of depression.

Also, patients in stable remission treated with esketamine nasal spray plus an oral antidepressant reduced the risk of relapse by 51 percent compared to patients receiving an oral antidepressant plus placebo nasal spray.

“The results from our Phase III studies reinforce the potential of esketamine nasal spray as a novel treatment to help patients who haven’t responded to available therapies,” said Husseini K. Manji, global head, Neuroscience Therapeutic Area, Janssen Research & Development.

“We look forward to bringing a new treatment option to people who need it most.”

Editor's Note:

To apply for becoming a contributor of,

welcome to send your CV and sample works to us,


Add a comment
Click here to Login or to Register for free. You will be taken back to your selected item after Login/Registration.
More>> MarketNews
More>> Editors’Picks
More>> TopStories
More>> HotTags
Follow Us
CPhI Online Trade Platform: Worldwide|English|中国站
Customer Service:  86-400 610 1188 (9: 00-18: 00, Mon-Fri)
About Us| Contact Us| Terms of Services| Privacy Policy| Intellectual Property Statement| Links | Site Map
Copyright 2006-20 Shanghai UBM Sinoexpo International Exhibition Co Ltd (All Rights Reserved). ICP 05034851-53
live chat