Join Free For Buyer|Sign In

Professional Online Trade Platform for API, Preparation and Pharmaceutical Machinery and

You are here:  Home >>  News >>  Research & Development >>  Postoperative Infection Rate Similar Across Biologics in RA

Postoperative Infection Rate Similar Across Biologics in RA

may 21, 2019 By drugs

For patients with rheumatoid arthritis (RA) undergoing arthroplasty, the risk for postoperative infection is similar across biologics but is increased with glucocorticoid use, according to a study published online May 21 in the Annals of Internal Medicine.

Michael D. George, M.D., from the University of Pennsylvania Perelman School of Medicine in Philadelphia, and colleagues compared the risk for postoperative infection among biologics and the risk associated with glucocorticoids in patients with RA undergoing arthroplasty. Data were included for 9,911 adults with RA treated with biologics who underwent 10,923 elective inpatient total knee or hip arthroplasty procedures.

The researchers found that patients who received different biologics had similar outcomes. For hospitalized infection, the predicted risk from propensity-weighted models ranged from 6.87 percent with adalimumab to 8.90 percent with rituximab compared with 8.16 percent with abatacept. For the one-year cumulative incidence of prosthetic joint infection (PJI), the predicted incidence ranged from 0.35 percent with rituximab to 3.67 percent with tocilizumab compared with 2.14 percent with abatacept. For all outcomes, glucocorticoids correlated with a dose-dependent increase in postoperative risk. Compared with no use, use of more than 10 mg of glucocorticoids per day resulted in a predicted risk for hospitalized infection of 13.25 versus 6.78 percent and a predicted one-year cumulative incidence of PJI of 3.83 versus 2.09 percent.

"Minimizing glucocorticoid exposure before surgery should be a primary focus of perioperative medication management," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Register as Visitor to CPhI China 2019!

Register as Visitor to CPhI China 2019!

Editor's Note:

If you have any suggestion to the content, 

please email:

Add a comment
Click here to Login or to Register for free. You will be taken back to your selected item after Login/Registration.
More>> MarketNews
More>> Editors’Picks
More>> TopStories
More>> HotTags
Follow Us
CPhI Online Trade Platform: Worldwide|English|中国站
Customer Service:  86-400 610 1188 (9: 00-18: 00, Mon-Fri)
About Us| Contact Us| Terms of Services| Privacy Policy| Intellectual Property Statement| Links | Site Map
Copyright 2006-20 Shanghai Sinoexpo Informa Markets International Exhibition Co. Ltd (All Rights Reserved). ICP 05034851-53
live chat